The Lancet ~ Volume 373, Issue 9657, Pages 1-94 (3 January by The Lancet PDF

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Additional resources for The Lancet ~ Volume 373, Issue 9657, Pages 1-94 (3 January 2009-9 January 2009)

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J Pediatr 1994; 125: 411–17. Using proxy information, Sara Kenyon and colleagues1 show that erythromycin and co-amoxiclav given to women in spontaneous preterm labour might result in more harm than good. With no objective evidence of abnormal genital-tract colonisation, these antibiotics might be causing harm by decimating normal flora rather than correcting abnormal flora. 2–5 The earlier in pregnancy at which spontaneous preterm birth occurs, the more likely this is to be due to an abnormal trigger such as infection.

Association between cerebral palsy and erythromycin In the ORACLE II follow-up study (Oct 11, p 1310),1 Sara Kenyon and colleagues report increased functional impairment and cerebral palsy among children who were exposed to erythromycin while their mothers were in preterm labour. We would like to draw attention to several key features of this trial that could affect the conclusions drawn. First, only a minority of women were actually in preterm labour and no objective criterion was applied to stratify women on the basis of infection.

Doctors’ responsibilities in child protection cases: guidance from the ethics department. London: BMA, 2004. nsf/ content/childprotection#Summary (accessed Dec 5, 2008). Association between cerebral palsy and erythromycin In the ORACLE II follow-up study (Oct 11, p 1310),1 Sara Kenyon and colleagues report increased functional impairment and cerebral palsy among children who were exposed to erythromycin while their mothers were in preterm labour. We would like to draw attention to several key features of this trial that could affect the conclusions drawn.

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